02 Nov 2022 --- Japan-based research findings may aid in the development of anti-aging skin treatments by preventing age-related changes in aging cells via the regulation of secreted frizzled-related protein 4 (SFRP4) expression.The study conducted by researchers from Keio University School of Medicine’s Department of Plastic and Reconstructive Surgery found that SFRP4 in the dermal fibroblasts of aging skin and its increased expression has been linked to cellular deterioration.