Researchers from Pohang University of Science and Technology (POSTECH), South Korea, make a “breakthrough” in understanding wrinkle formation by developing an in vitro model that mimics the structure of wrinkles in biological tissues. The study in Nature Communications was led by Professors Dong Sung Kim and Anna Lee with contributions from Dr. Jaeseung Youn from the Department of Mechanical Engineering. They explored the role of extracellular matrix (ECM) dehydration and compressive forces in wrinkle formation.