Shiseido unveils two studies to tackle aging skin concerns. The Japanese beauty giant says cytotoxic CD4+ T cells (CD4 CTL) and fermented camellia seed extract can eliminate aged fibroblasts or senescent cells, which are known to cause aging as they stop multiplying and don’t die off when they should. CD4 CTL is an immune T cell abundant in long-lived people, considered “models of ideal health and longevity.”