14 Jun 2023 --- Shiseido has pinpointed the biological mechanisms of special proteins affecting the aging of skin cells, also referred to as the process of senescence. The Japanese beauty brand worked with US-based scientists at the Cutaneous Biology Research Center (CBRC) at Massachusetts General Hospital for a total of five years to understand this occurrence. The researchers discovered the influence of a specific protein called YBX1. When this protein is “phosphorylated” (modified by attaching phosphate groups), it leads to the aging of skin cells because this reduces its functions.